Ebola overview

Pin3 Shares 27 Ebola virus disease EVDmore commonly referred to as Ebola, is a rare and severe illness that can often be fatal.

Ebola overview

Signs and symptoms of Ebola [17] Onset The length of time between exposure to the virus and the development of symptoms incubation period is between 2 and 21 days, [1] [17] and usually between 4 and 10 days.

The most abundant protein produced is the nucleoprotein, whose concentration in the host cell determines when L switches from gene transcription to genome replication. Replication of the viral genome results in full-length, positive-strand antigenomes that are, in turn, transcribed into genome copies of negative-strand virus progeny.

Virions bud off from the cell, gaining their envelopes from the cellular membrane from which they bud. The mature progeny particles then infect other cells to repeat the cycle.

Ebola virus - an overview | ScienceDirect Topics

Most people spread the virus through blood, feces and vomit. In Africa, wild animals including fruit bats are hunted for food and are referred to as bushmeat. However, the high rates of death in these species resulting from EBOV infection make it unlikely that these species represent a natural reservoir for the virus.

Ebola overview

Index cases of EVD have often been close to recently-deforested lands. This damage occurs due to the synthesis of Ebola virus glycoprotein GPwhich reduces the availability of specific integrins responsible for cell adhesion to the intercellular structure and causes liver damage, leading to improper clotting.

The widespread bleeding that occurs in affected people causes swelling and shock due to loss of blood volume.


EBOV replication overwhelms protein synthesis of infected cells and the host immune defenses. The GP forms a trimeric complexwhich tethers the virus to the endothelial cells.

The sGP forms a dimeric protein that interferes with the signaling of neutrophilsanother type of white blood cell. This enables the virus to evade the immune system by inhibiting early steps of neutrophil activation. Immune system evasion Filoviral infection also interferes with proper functioning of the innate immune system.

Laboratory testing Possible non-specific laboratory indicators of EVD include a low platelet count ; an initially decreased white blood cell count followed by an increased white blood cell count ; elevated levels of the liver enzymes alanine aminotransferase ALT and aspartate aminotransferase AST ; and abnormalities in blood clotting often consistent with disseminated intravascular coagulation DIC such as a prolonged prothrombin timepartial thromboplastin timeand bleeding time.

Isolating the virus by cell culturedetecting the viral RNA by polymerase chain reaction PCR [18] and detecting proteins by enzyme-linked immunosorbent assay ELISA are methods best used in the early stages of the disease and also for detecting the virus in human remains.

Detecting antibodies against the virus is most reliable in the later stages of the disease and in those who recover.With member countries, staff from more than countries, and offices in over locations, the World Bank Group is a unique global partnership: five institutions working for sustainable solutions that reduce poverty and build shared prosperity in developing countries.

Three health zones reported their first confirmed Ebola cases recently, a worrisome sign. Ebola virus disease (EVD), more commonly referred to as Ebola, is a rare and severe illness that can often be fatal. On average EVD fatalities is a result of fifty percent of all cases.

Ebola virus is detected in blood only after onset of symptoms, most notably fever It may take up to 3 days post-onset of symptoms Ebola Overview Template.

Ebola Virus Infection: Practice Essentials, Background, Pathophysiology and Etiology

Ebola is a serious and deadly virus transmitted by animals and humans. It was initially detected in in Sudan and the Democratic Republic of Congo.

Researchers named the disease after the. Ebola virus disease (EVD), also known as Ebola hemorrhagic fever (EHF) or simply Ebola, is a viral hemorrhagic fever of humans and other primates caused by ebolaviruses.

Signs and symptoms typically start between two days and three weeks after contracting the virus with a fever, sore throat, muscular pain, and headaches. Vomiting, diarrhea and rash usually follow, along with decreased function.

Ebola overview
Ebola virus disease - Wikipedia